Choroid Plexus Cysts
Choroid Plexus Cysts are a well-known ultrasound aneuploidy marker and are easily detectable at second-trimester ultrasound examination, showing an incidence in euploid fetus close to 1 percent and a positive predictive value of 1 to 6 percent.
The association with other fetal anomalities, their bilateralism, a diameter bigger than 10 mm and their persistence after 22 to 24 weeks have been classical indication for cytogenetic fetal study. A prospective study of advanced age women found that if fetal CPCs appear to be isolated, genetic amniocentesis is not mandatory and additional risk factors such as advanced maternal age should be the main indication for fetal karyotyping .
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